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Leukoencephalomyelopathy (LEMP)

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Description:

Orivet, a leader in innovative animal health, provides over 260 Tests for Dog Breeders.

 

Leukoencephalomyelopathy (LEMP) is a neurological disorder which impacts the central nervous symptoms (CNS).  Symptoms for LEMP appear within 1 to 4 years of age and like many diseases of the CNS there is no effective treatment.  The genetic test allows you to screen for the disease in the Rottweiler and Great Dane at an early age. Please see more in Test Overview below. 

Test Overview:

Symptoms of Leukoencephalomyelopathy in affected dogs include: inability to control bodily movements, inability to judge distance, generalized muscle weakness, hypermetria, and exaggerated spinal reflexes. Neuronal examination revealed myelin breakdown, followed by swelling of the axons. Due to the progressive derogative nature of the disorder, affected dogs are usually euthanized. The symptoms usually appear at animal’s young age.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

NAPEPLD

Variant Detected:

Insertion

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Oevermann, A., Bley, T., Konar, M., Lang, J. and Vandevelde, M. (2008): A novel leukoencephalomyelopathy of Leonberger dogs. Journal of Veterinary Internal Medicine, 22: 467–471. doi:10.1111/j.1939-1676.2008.0068.x Minor KM, Letko A, Becker D, et al. (2018) Canine NAPEPLD-associated models of human myelin disorders. Scientific Reports 8, Article number: 5818. doi:10.1038/s41598-018-23938-7

Associated Breed(s):

Great Dane, Rottweiler ,

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