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Harlequin (H) Pattern (Great Dane Type)

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Test Overview:

The Harlequin gene causes a white background and the spots increase in size. Dogs that are not merle, cannot express the Harlequin colour/pattern. Breeding two dogs that both have a copy of the h locus “NH” is not recommended. A dog with two copies of Harlequin has not been observed and It is presumed to be lethal in utero. This gene is inherited as a dominant trait.

Category:

Trait (Associated with Phenotype)

Gene:

PSMB7

Variant Detected:

Base Substitution T>C

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Dominant

Research Citation(s):


Gene. 2008 Jul 15; 418(1-2):49-52. [PubMed: 18513894]
. Genomics. 2011 Apr; 97(4):244-8. [PubMed: 21256207]

Associated Breed(s):

Great Dane, Harlequin Pinscher, Mixed Breed,
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