Category:
Nervous system / Neurologic - Associated with the brain, spinal cord and nerves
Gene:
Superoxide dismutase 1 (SOD1) on chromosome 31
Variant Detected:
Base Substitution
c.118G>A
p.Glu40Lys
Severity:
Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected
animals. It may involve relatively high treatment/management costs, and can sometimes reduce life
expectancy.
Mode of Inheritance:
Autosomal Recessive with Incomplete Penetrance
Recommended Screening:
1. All breeding animals should have a DNA test prior to entering into a breeding program - eg at 1 year of age.
2. Neurologic examination of all animals at annual veterinary check-up from middle age (3-4 years) onwards.
3. Offer DNA testing to all owners of puppies if his parents have not been screened.
Research Citation(s):
Awano T, et al. Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis (2009)Proc Natl Acad Sci;106(8);2794-2799.
Associated Breed(s):
Alaskan Malamute,
American Bulldog ,
American Bully ,
American Cocker Spaniel,
American Eskimo Dog,
American Hairless (Rat) Terrier,
American Pit Bull Terrier,
Australian Bulldog,
Australian Cattle Dog,
Australian Cobberdog,
Australian Labradoodle ,
Australian Shepherd,
Australian Silky Terrier,
Australian Terrier,
Barbet,
Beagle,
Belgian Lakenois Shepherd,
Belgian Malinois Shepherd,
Belgian Tervueren Shepherd ,
Bernardoodle,
Bernese Mountain Dog,
Bichon Frise,
Bloodhound,
Boerboel,
Border Collie,
Borzoi,
Boston Bulldog,
Boxer ,
Boykin Spaniel,
British Bulldog,
Bullmastiff,
Canaan Dog,
Cane Corso Italiano,
Cardigan Welsh Corgi,
Catahoula,
Cavador,
Cavalier King Charles Spaniel,
Cavoodle,
Chesapeake Bay Retriever ,
Chinese Crested,
Chow Chow,
Collie Rough,
Collie Smooth,
Coton De Tulear,
Curly Coated Retriever,
Dutch Shepherd,
English Springer Spaniel,
English Toy Terrier,
Finnish Lapphund,
French Bulldog,
German Pinscher,
German Shepherd Dog,
Glen of Imaal Terrier,
Golden Retriever,
Goldendoodle,
Great Dane,
Great Pyrenees,
Groodle,
Harlequin Pinscher,
Irish Setter,
Irish Wolfhound,
Kerry Blue Terrier,
King Charles Spaniel,
Koolie ,
Labradoodle ,
Labradoodle Retrodoodle ,
Labrador Retriever,
Landseer ECT,
Maremma Sheepdog,
Miniature Pinscher ,
Miniature Poodle,
Mixed Breed,
Moodle,
Moyen Poodle,
Norfolk Terrier ,
Norwich Terrier,
Nova Scotia Duck Tolling Retriever ,
Old English Sheepdog ,
Patterdale Terrier,
Pembroke Welsh Corgi,
Pomeranian,
Portuguese Water Dog,
Pug,
Puli,
Rat Terrier,
Rhodesian Ridgeback ,
Rottweiler ,
Saint Bernard ,
Scottish Terrier ,
Shetland Sheepdog,
Shih tzu,
Shortybull,
Soft Coated Wheaten Terrier,
Spoodle,
Staffordshire Bull Terrier ,
Standard Poodle,
Tenterfield Terrier ,
Tibetan Spaniel,
Tibetan Terrier ,
Toy Poodle,
Wallace Bulldog,
Welsh Terrier ,
White Swiss Shepherd,
Wire Fox Terrier,