Store
Already have an Orivet Account? Enter your information here
Ichthyosis (Great Dane)
Test Overview:
Macroscopically, all dogs showed generalized gray to yellow scaling and skin wrinkles on the head and all 4 extremities. Skin sections were histologically examined using hematoxylin and eosin, Heidenhain's Azan, and Sudan red III staining methods and by conducting the alcian blue/periodic acid Schiff (AB/PAS) reaction technique on sections.
Category:
Dermatologic - Associated with the skin
Gene:
Solute carrier family 27 member 4 (SLC27A4) Chromosome 9
Variant Detected:
Base Substitution c.1268G>A p.Arg417Gln
Severity:
Low. This disease generally causes mild signs of disease, or can be quite easily treated/managed.
Mode of Inheritance:
Autosomal Recessive
Research Citation(s):
Metzger, A Novel SLC27A4 Splice Acceptor Site Mutation in Great Danes with Ichthyosis. 2015, PLoS ONE 10(10): e0141514
Associated Breed(s):
Great Dane, Mixed Breed,
