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Neuroaxonal Dystrophy (Rottweiler Type)

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Description:

Neuroaxonal dystrophy (NAD) in Rottweiler dogs is a degenerative neurological disease. Signs are first apparent in young adults as uncoordinated movement (ataxia) and overstepping/high-stepping an intended location (hypermetria). Additional signs may include tremors and involuntary eye movements (nystagmus).
The disease is inherited in an autosomal recessive fashion, which means that males and females are equally affected and that two copies of the defective gene are needed to cause NAD. Dogs with one normal and one affected gene (carriers) are normal and show no signs of the disease.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

VSP11

Variant Detected:

c.2504A>G

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

G3 (Bethesda). 2018 Aug; 8(8): 2773–2780

Associated Breed(s):

Mixed Breed, Rottweiler ,

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