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Congenital Deafness (Cattle Dog Type) (LINKAGE CANDIDATE GENE)

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Description:

-

Test Overview:

Congenital sensorineural deafness, an inherited condition, affects numerous dog breeds, including Australian Stumpy-tail Cattle Dogs (ASCD). This form of deafness is typically noticeable in young pups and can impact either one ear (unilateral) or both ears (bilateral). The exact genetic locations responsible for this condition remain unidentified across all breeds. In congenital cochleosaccular deafness, the degeneration of strial cells is linked to the absence of melanocytes, which are essential pigment-producing cells. These melanocytes are crucial for the survival of the stria vascularis, which helps maintain the cochlear environment necessary for the health of hair cells. The lack of melanocytes might explain why breeds with reduced pigmentation often experience deafness. This includes breeds with diluted coat and eye colors, like the merle Border Collie, or those with piebald or predominantly white coloring, such as Bull Terriers and Dalmatians. Although a 2004 study on Australian Cattle Dogs did not find a correlation between pigmentation and deafness in 293 animals, there has been no specific research published on the ASCD concerning this association.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

KLF7

Variant Detected:

g.15562684G>A chr37

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive with Incomplete Penetrance

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/33805165/

Associated Breed(s):

Australian Cattle Dog, Australian Stumpy Tail Cattle Dog,

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