Category:

Urinary system / Urologic - Associated with the kidneys, bladder, ureters and urethra

Gene:

Solute carrier family 2 member 9 (SLC2A9) on chromosome 3

Variant Detected:

Base Substitution c.563G>T p.Cys188Phe

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Bannasch D, et al. Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog. (2008), PLOS genet, 4;11,e1000246
Bannasch, D., Young, A., Myers, J., Truve, K., Dickinson, P., Gregg, J., Davis, R., Bongcam-Rudloff, E., Webster, M.T., Lindblad-Toh, K., Pedersen, N. : Localization of canine brachycephaly using an across breed mapping approach. PLoS One 5:e9632, 2010. Pubmed reference: 20224736. DOI: 10.1371/journal.pone.0009632.

Associated Breed(s):

American Bulldog , American Bully , American Pit Bull Terrier, Anatolian Shepherd, Australian Bulldog, Australian Cattle Dog, Australian Cobberdog, Australian Labradoodle , Australian Shepherd, Black Russian Terrier , Boerboel, Boston Bulldog, British Bulldog, Dalmatian, Finnish Lapphund, French Bulldog, German Shepherd Dog, Giant Schnauzer, Goldendoodle, Groodle, Harlequin Pinscher, Hungarian Vizsla, Jack Russell Terrier, Koolie , Labradoodle , Labradoodle Retrodoodle , Labrador Retriever, Lagotto Romagnolo, Large Munsterlander, Miniature American Shepherd, Mixed Breed, Parson Russell Terrier, Pomeranian, Short Bully, Shortybull, Swedish Vallhund, Weimaraner, Weimaraner Long Hair , White Swiss Shepherd,