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Sensory Neuropathy (Border Collie Type)

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Test Overview:

Sensory neuropathy Border Collie type is an inherited progressive neurological disorder which affects the Border Collie breed. Generally, neuropathy is a disease of the peripheral nerves. The peripheral nervous system is responsible for sensation feeling to the skin and the muscle control. Disease of the sensory nerves causes the sensory neuropathy. Sensory neuropathy can be divided into two groups, inherited or acquired through disease processes or trauma. Inherited sensory neuropathy is a rare disorder but has been reported in several countries worldwide. Affected dogs start to show symptoms between the ages of 5 and 7 months. Clinical signs include loss of coordination, joint laxity, lack of awareness where the limbs are in space, and inability to perceive pain. Affected dogs often have self-mutilated limbs, which may be due to tingling or pain in their paws, another manifestation of the disorder. Since the disorder is progressive and the symptoms are severe, affected dogs are usually euthanized.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

FAM134B

Variant Detected:

Inversion

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Forman OP, Hitti RJ, Pettitt L, Jenkins CA, O’Brien DP, Shelton GD, Risio LD, Quintana RG, Beltran E, Cathryn Mellersh. An inversion disrupting FAM134B is associated with sensory neuropathy in the Border Collie dog breed. G3 (Bethesda). 2016 Sep 8;6(9):2687-92.

Associated Breed(s):

Border Collie, Bordoodle, Koolie , Smithfield,

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