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Neuroaxonal dystrophy (NAD) in Rottweiler dogs is a degenerative neurological disease. Signs are first apparent in young adults as uncoordinated movement (ataxia) and overstepping/high-stepping an intended location (hypermetria). Additional signs may include tremors and involuntary eye movements (nystagmus).
The disease is inherited in an autosomal recessive fashion, which means that males and females are equally affected and that two copies of the defective gene are needed to cause NAD. Dogs with one normal and one affected gene (carriers) are normal and show no signs of the disease.
Category:
Nervous system / Neurologic - Associated with the brain, spinal cord and nerves
Gene:
PPT1
Variant Detected:
G>A Chr15:2860424
Severity:
Severe. This disease has a high impact on affected animals, either with severe clinical signs causing significant suffering, or carrying a rapidly fatal course.
Mode of Inheritance:
Autosomal Recessive
Associated Breed(s):
Cane Corso Italiano, Mixed Breed,