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May-Hegglin Anomaly (Pug Type)
Test Overview:
an inherited blood cell disorder. Symptoms include reduced numbers of platelets (normal sized), together with the presence of larger and abnormal platelets.
Category:
Haemolymphatic - Associated with the blood and lymph
Gene:
Myosin heavy chain 9 (MYH9) on Chromosome 10
Variant Detected:
Base Substitution c.5600G>A p.Glu1842Lys
Severity:
Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.
Mode of Inheritance:
Autosomal Recessive
Research Citation(s):
Flatland B, et al. May-Hegglin anomaly in a dog. (2009) Vet Clin Path 40(2); 207-214.
Associated Breed(s):
Mixed Breed, Pug,
