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Canine Multiple System Degeneration (Kerry Blue Terrier Type)
$50.00 (RRP)
$50.00 (MEMBER PRICE)
Description:
This is a hereditary movement disorder. Affected pups develop normally until about 4 months of age. Then their head starts to shake when they focus on something, and rather than becoming stronger and more coordinated, they develop exaggerated, goose-stepping movements (cerebellar ataxia). Dogs can function with cerebellar ataxia, but CMSD progresses to a more severe movement disorder by 12-18 months of age. Affected dogs have difficulty even starting a movement and fall frequently. They become incapacitated by 2 years of age.
Category:
Nervous system / Neurologic - Associated with the brain, spinal cord and nerves
Gene:
Serine active site containing 1 (SERAC1) on chromosome 1
Variant Detected:
c.1536G>A p.Trp512STOP
Severity:
It is a trait and so is tested based on preference, not usually for health concerns.
Mode of Inheritance:
Autosomal Recessive
Research Citation(s):
J Hered. 2005;96(7):727-34
Associated Breed(s):
Kerry Blue Terrier, Mixed Breed,
