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Canine Multiple System Degeneration (Chinese Crested)

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Test Overview:

Canine multiple system degeneration (Chinese crested type) and (kerry blue type) is a progressive inherited neurological disease affecting Chinese crested dogs. Affected dogs present at 3 to 6 months of age with tremors, abnormal gait and poor balance. Dogs gradually progress to severe gait abnormalities, balance issues, frequent falling, abnormal body posture, abnormal eye movement and eventually are unable to move.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

SERAC1

Variant Detected:

del GTAA and point mutation G>C

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Johnson GS, Mhlanga-Mutangadura T, Morava E, Kozicz T, Taylor JF, O’Brien DP, Schnabel RD. Canine Multiple System Degeneration is Associated with Distinct SERAC1 Mutations in Two Different Dog Breeds [abstract]. Presented at the 63rd Annual Meeting of the American Society of Human Genetics in Boston, Massachusetts; 2013 Oct 22-26.

Associated Breed(s):

Chinese Crested,

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