Dilute (MLPH)

$50.00 (RRP)

$50.00 (MEMBER PRICE)

Test Overview:

The MLPH gene affects feline coat colour. It does so by modifying the expression of pigments, eumelanin and phaeomelanin in cats hair. This results in a dilution or lightening of their coat colour. Variants of the MLPH gene are expressed with an autosomal recessive manner with D being dominant (and expressed) over d. Cats who have D/D and D/d genotypes have normal, non-diluted coat colour, whereas cats who have d/d genotype have a diluted coat colour. However, the cats base coat colour depends on other genes in their genome, and include loci A, O, B, E and C.

Category:

Trait (Associated with Phenotype)

Gene:

MLPH

Variant Detected:

c.83delT

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Ishida Y, David VA, Eizirik E, Schaffer AA, Neelam BA, Roelke ME, Hannah SS, O'Brien SJ, Menotti-Raymond M. A homozygous single-base deletion in MLPH causes the dilute coat color phenotype in the domestic cat. Genomics. 2006 Dec;88(6):698-705. PubMed PMID: 16860533 PubMed: 16860533

Associated Breed(s):

Abyssinian, African Short Hair, American Bobtail , American Curl, American Ringtail, American Shorthair, Angora, Asian, Australian Mist , Balinese, Bambino, Bengal, Birman, Bombay, British Black Tipped, British Longhair, British Red Spot, British Shorthair, British Shorthair/Longhair, Burmese, Burmilla, Calico, California Spangled, Chantilly, Chartreux, Chausie, Cheetoh, Chinchilla, Colourpoint Shorthair, Colourpoint Siberian Forest Cat, Cornish Rex, Devon Rex, Domestic Leopard Cat, Domestic Medium / Long Hair, Domestic Short Hair, Don Hairless, Don Sphynx, Egyptian Black, Egyptian Mau, Elf Cat, European, Exotic , Exotic Longhair, Exotic Shorthair, Foreign White, German Rex, Havana Brown, Highland Fold, Himalayan, Japanese Bobtail, Javanese, Khao Manee, Korat, Kurilian Bobtail Short Haired, LaPerm , Lykoi, Maine Coon, Mandalay, Manx , Minuet, Mixed Breed / Unknown Breed (Feline), Munchkin Short/Long Haired, Neva Masquerade, Norwegian Forest Cat, Ocicat, Ojos Azules, Oriental , Oriental Long Hair, Oriental Short Hair, Persian , Persian Blue, Persian Colourpoint, Persian Smoke, Persian Tabby, Peterbald, PixieBob, Ragamuffin, Ragdoll, Rex , Russian Black, Russian Blue, Russian White, Savannah, Scottish Fold, Scottish Fold Long Haired, Scottish Fold Short Haired, Scottish Short Hair, Scottish Straight, Scottish Wildcat, Selkirk Rex, Serengeti, Seychellois Short/Long Hair, Siamese, Siberian, Siberian Forest Cat, Singapura, Snowshoe, Sokoke, Somali , Somali Long Hair, Somali Short Hair, Sphynx, Tiffany, Tonkinese, Toybob, Toyger, Turkish Angora, Turkish Van, York Chocolate,
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