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Hypokalaemia Periodic Polymyopathy - Burmese
Test Overview:
Hypokalemia, a subnormal serum potassium ion concentration ([K+]), most often occurs as a secondary problem but can occur as a primary problem, such as hypokalaemic periodic paralysis in humans, and as feline hypokalaemic periodic polymyopathy primarily in Burmese. The most characteristic clinical sign of hypokalemia in Burmese is a skeletal muscle weakness that is frequently episodic in nature, either generalized, or sometimes localized to the cervical and thoracic limb girdle muscles. Burmese hypokalemia is suspected to be a single locus autosomal recessive trait.
Category:
Metabolic - Associated with the enzymes and metabolic processes of cells
Gene:
WNK4
Variant Detected:
Base Substitution C>T
Severity:
Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.
Mode of Inheritance:
Autosomal Recessive
Research Citation(s):
PLoS One. 2012;7(12):e53173
Associated Breed(s):
Asian, Australian Mist , Bombay, Burmese, Burmilla, Cornish Rex, Devon Rex, Singapura, Sphynx, Tonkinese,