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Eh Locus (Sable, Cocker Spaniel Type)
Test Overview:
The genetic locus EH plays a pivotal role in determining the unique sable coat coloration seen in American and English Cocker Spaniels. Dogs that carry this allele display a notable reduction in the expression of eumelanin pigment, leading to a lighter coat. This results in a distinct color gradient that transitions from golden hues to richer browns, typically concentrated on the dog’s head and back. Genetic studies have identified a specific mutation, c.250G>A, within the transmembrane domain of the MC1R gene, consistently present in dogs exhibiting the sable color phenotype.
Category:
Trait (Associated with Phenotype)
Gene:
MR1
Variant Detected:
c.250G>A
Severity:
It is a trait and so is tested based on preference, not usually for health concerns.
Mode of Inheritance:
Dominant with Variable Expressivity
Associated Breed(s):
American Cocker Spaniel, Cockapoo, Cocker Spaniel,