Category:

Ophthalmologic - Associated with the eyes and associated structures

Gene:

ADAM metallopeptidase with thrombospondin type 1 motif 10 (ADAMTS10) on Chromosome 20

Variant Detected:

Base Substitution c.1441G>A p.Ala387Thr

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Ahonen, SJ. A Novel Missense Mutation in ADAMTS10 in Norwegian Elkhound Primary Glaucoma (2014) PLoS One 9(11); e111941.

Associated Breed(s):

Mixed Breed,