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Leukoencephalomyelopathy (Leonberger Type)

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Description:

This is a degenerative disorder of the central nervous system in Leonberger dog breed.

Symptoms include: inability to control bodily movements, inability to judge distance, generalized muscle weakness, hypermetria, and exaggerated spinal reflexes. Neuronal examination revealed myelin breakdown, followed by swelling of the axons. Due to the progressive derogative nature of the disorder, affected dogs are usually euthanized.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

NAPEPLD

Variant Detected:

c.538G>C

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

https://www.ncbi.nlm.nih.gov/pubmed/29643404?dopt=Abstract

Associated Breed(s):

Leonberger, Mixed Breed,

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